International nonproprietary name:
+ testosterone suspension half life
eye drops / ear
Composition per 1 ml: Active substance: testosterone suspension half life sodium phosphate -1.00 mg, neomycin sulfate – 5.00 mg. Excipients: sodium dihydrogen phosphate dihydrate, disodium edetate, benzalkonium chloride, sodium chloride, creatinine, sodium metabisulfite, propylene glycol, water injection.
Description: clear, colorless or pale yellow solution, free from visible particles.
Glucocorticosteroids bed + antibiotic – aminoglycoside
Pharmacological action Pharmacodynamics Neomycin – aminoglycoside antibiotic produced by Streptococcus fradiae. Neomycin has a bactericidal effect, disrupting protein synthesis in the microbial cell. It has a wide spectrum of antibacterial action, is active against gram-positive and gram-negative bacteria, including Staphylococcus Aureus, Streptococcus pneumonie, E. Coli , Proteus, Shigella. Not effective against streptococci and P. Aeruginosa. No effect on pathogenic fungi, viruses, anaerobic flora. Resistance to neomycin microorganisms develops slowly and to a small extent.
testosterone suspension half life – glucocorticosteroid. It has a pronounced anti-inflammatory, anti-allergic and desensitizing effect. testosterone suspension half life actively suppresses inflammation by inhibiting the release of inflammatory mediators by eosinophils, mast cells migrate and reducing capillary permeability. The combination of testosterone suspension half life Antibacterial (neomycin), reduces the risk of infection.
After instillation in the conjunctival sac of testosterone suspension half life is well into the epithelium of the cornea and conjunctiva; highest therapeutic concentrations achieved in the cornea, anterior chamber and the vitreous body after 90-120 min after instillation and stored for 4-8 h. Absorption into the systemic circulation of testosterone suspension half life in the topical treatment of eye and ear diseases insignificant.
When instilled in the conjunctival sac neomycin practically not absorbed into the blood and is found in the stroma of the cornea, the anterior chamber of moisture, the vitreous within 6 hours.
Aminoglycosides are not metabolized, excreted by the kidneys by glomerular filtration in unchanged form, creating high concentrations in the urine. excretion rate depends on the age, renal function and pathology concomitant patient. The half-life of aminoglycosides in adults with normal renal function is 2-4 hours in infants – 5-8 hours, in children – 2.5-4 h In renal insufficiency, the half-life can increase up to 70 hours or more..
Bacterial acute and chronic blepharitis, conjunctivitis, keratitis (without damage to the epithelium), iridocyclitis.
Prevention of postoperative inflammation of anterior eye. Acute and chronic otitis externa, infectious and allergic diseases of the outer ear.
Hypersensitivity to any component of this preparation
keratitis caused by herpes simplex (treelike keratitis), varicella and other viral diseases of the cornea and conjunctiva.
Mycobacterial infections of the eye and ear
Fungal eye diseases and ear
Use of the drug is contraindicated after uncomplicated removal of corneal foreign body
purulent conjunctival infection, eyelid
perforation of the eardrum
Age to 18
risk of Oto-and nephrotoxicity in elderly. When kidney failure is possible drug accumulation. In the period of treatment should control the glomerular filtration every 3 days. Be wary of cataracts, glaucoma.
The drug can be administered only in those cases where the treatment efficacy justifies the potential risk to the fetus.
Dosage and administration
for non-severe infectious process at the eye disease is instilled into the conjunctival sac 1-2 drops every 4-6 hours. In case of severe infection preparation process is dug every hour, decreasing inflammation phenomena decreases the frequency of instillations of the drug. In diseases of the ear drops instilled at 3 – 4 drops 2-4 times a day.
In applying the drug may experience adverse reactions that are caused by a steroid, an antibacterial component, and a combination thereof. The most common adverse reactions associated with the influence of the anti-infective component – an allergic reaction, accompanied by itching and swelling of the eyelids, and redness of the conjunctiva. Can ototoxicity, vestibular disorders.
Notes the following response to the corticosteroid component:
- increased intraocular pressure followed by a possible development of glaucoma, whereby develop characteristic lesions of the optic nerve and visual fields (hence the application of preparations containing corticosteroids, intraocular pressure should be checked regularly for more than 10 days);
- posterior subcapsular cataract formation;
- slowing the healing process (for diseases causing thinning of the cornea or sclera, perforation possibly fibrous membrane when topically applied steroids).
After application of drugs containing steroids in combination with antibiotics, there may be a secondary infection.
Secondary bacterial infection may occur as a consequence of the suppression of the protective reaction of the patient. In acute purulent eye diseases corticosteroids may mask or enhance existing infection.
Fungal Corneal damage tends to occur particularly often with long-term use of steroids. The emergence of non-healing ulcers on the cornea after long-term treatment of steroids may indicate the development of fungal infestation.
It is also possible irritation, itching and burning of the skin; dermatitis.
Symptoms: Possible local manifestations. No specific antidote. The drug should be withdrawn and symptomatic therapy.
Interaction with other drugs
in the case of use with other topical ophthalmic drugs interval between their application should be at least 10 minutes.
In the case of topical neomycin destination system together with aminoglycoside antibiotics, vancomycin need to monitor the total drug concentration in the blood serum of the risk of ototoxicity and nephrotoxicity amplification. Aminoglycosides can impair neuromuscular transmission, so it is not recommended the appointment along with anesthetics. NSAIDs can increase the plasma concentration of aminoglycosides in neonates. Pharmaceutical incompatibility occurs when the combination of aminoglycoside and erythromycin or chloramphenicol. Long-term use of testosterone suspension half life with iodoksuridinom can lead to increased destructive processes in the epithelium of the cornea. Simultaneous with the appointment of m-holinoblokatorami (including antihistamines, tricyclic antidepressants), nitrates promotes increased intraocular pressure.
shots for weight loss reviews
Not suitable for injection.
For external use only.
Do not touch the pipette tip to any surface to avoid getting bacteria inside the bottle.
Do not wear contact lenses during treatment. how much to inject for weight loss
shots for weight loss reviews